Highlights:
1. Applications are invited for a post-doctoral research scientist to work with Dr. Alessio Ciulli in the Department of Chemistry on an interdisciplinary programme developing a novel fragment-based strategy to investigate the druggability of protein-protein interfaces with respect to modulation by small molecules, and implications for drug design.
2. The project will involve applying a combination of protein engineering and biophysical and structural techniques to study protein-ligand and protein-protein molecular recognition, including protein X-ray crystallography, NMR spectroscopy, isothermal titration calorimetry and surface plasmon resonance. For a review of our fragment-based approach see Curr. Opin. Biotech. 2007, 18(6), 489-496.
3. The successful candidate will have the opportunity to join the Cambridge Molecular Therapeutics Programme (see http://www.cmtp.cam.ac.uk/CMTP_intro.html ), a collaborative and interdisciplinary initiative based at Cambridge to explore new strategies for the discovery and development of drugs against disease such as cancer and tuberculosis. The laboratories are exceptionally well equipped with state-of-the-art equipment for all aspects of modern chemical and structural biology.
4. Applicants should have (or be about to receive) a PhD in chemistry, biochemistry, structural biology, or a related area. Experience in molecular biology, protein purification and with appropriate biophysical techniques is essential; some experience in synthetic organic chemistry would be advantageous. The ability to work in a creative and dynamic research environment at the interface of chemical biology and drug discovery is paramount. Further information can be found at http://www-abell.ch.cam.ac.uk/group/alessio.html.
5. The post is available from 1st January 2010. Applications should include a CV, publications list, contact details for three professional referees, and a completed form PD18 Parts I and III (downloadable from http://www.admin.cam.ac.uk/offices/hr/forms/pd18/ ), and should be sent to Dr Alessio Ciulli, Department of Chemistry, Lensfield Road, Cambridge CB2 1EW (email: ac313@cam.ac.uk).
6. The funds for this post are available for five years in the first instance.
7. Closing date: 21 October 2009.
8. The University values diversity and is committed to equality of opportunity.
9. Salary: £27,183-£35,469
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