Highlights:
1. The Scientist, Chemistry position is responsible for developing, updating and validating synthetic, purification and/or analytical procedures to support Chemistry and Process Development projects in the area of nucleic acid chemistry.
2. RESPONSIBILITIES: Development of project study plans and protocols, interim and final development reports, and SOPs, exercising a significant degree of scientific independence
3. Presentation of study designs and final results
4. Develop/update and validate scalable synthetic and/or purification procedures (including prep HPLC), and/or analytical methods (HPLC; LC/MS; quantitative UV/Vis; and 1H, 13C, 31P NMR) for key starting materials; unnatural nucleosides and nucleotides; phosphoramidites; and standard (unlabeled) and dyelabeled phosphodiester oligonucleotides (oligos)
5. Assist in the analysis of finished lots of phosphoramidites, single oligos, and oligo mixes Assist in the manufacturing of nucleosides, nucleotides, and phosphoramidites, as needed Detailed record keeping of experimental strategy and all experiments in a laboratory notebook or on production records as required (analytical, synthesis and/or purification procedures, and corresponding analytical data)
6. Train coworkers on newly developed or updated SOPs
7. Train and guide less experienced coworkers on laboratory equipment and procedures, and in safety Maintain supplies of commonly used chemicals and materials needed for chemistry group
8. Maintain good awareness of advances in nucleic acid chemistry
9. Other duties as required
10. REQUIREMENTS: BS/BA or MS (with 3 years relevant post-graduate experience) or PhD in analytical or organic chemistry, chemical biology, chemical engineering, or related field.
11. Experience with nucleic acid chemistry and analysis is strongly preferred.
12. Experience with equipment and instrumentation used in the synthetic organic and/or analytical chemistry laboratories
13. Organic chemistry experience working with up to the 5L scale is a plus
14. Experience with Good Manufacturing Practices (GMP) is a plus
15. High degree of attention to detail in the laboratory
16. Capable of independent problem solving and analytical skills
17. Strong organizational and time-management skills
18. Must be able to travel locally (within 20 miles) on regular basis and out-of-area infrequently.
19. Excellent interpersonal, verbal and written communication skills
20. EraGen Biosciences is an equal opportunity employer.
21. Please email cover letter and resume (including reference to Job Code) to:
EraGen Biosciences
Human Resources
918 Deming Way, Suite 201
Madison, WI 53717
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