Postdoctoral Research Fellow(This post is available from 1 September 2009 for a fixed-term of 3 years)
Project title: Transcriptional control of multinucleated giant cells and osteoclasts Macrophages are able to fuse and differentiate into either multinucleated giant cells or osteoclasts. We have identified a novel transcriptional regulator that represses both multinuclear cell fates during macrophage development. This project will use ChIP-Seq in conjunction with bio-informatics to identify the target genes of the repressor during macrophage development and generate conditional knockout mice to genetically establish the role of this repressor in myelopoiesis.
You will have a recent PhD (or soon to be awarded) with a strong emphasis in molecular biology, cell biology, immunology or genetics. You will have practical experience in the culture of haematopoietic cells, recombinant DNA procedures and gene expression analysis. Knowledge of gene regulation in the haematopoietic system and a good understanding of modern concepts of gene regulation are required.
The Section of Experimental Haematology is a vigorous and highly interactive department, consisting of faculty members studying the molecular regulation of cell fate specification and differentiation during blood cell development. This is complimented by studies on the dysregulation of haematopoiesis in cancers (leukemias and lymphomas). You will join the Leeds Institute of Molecular Medicine (LIMM), a world-class multi-disciplinary research institute, dedicated to defining the molecules involved in human diseases.
University Grade 7 (£29,704 – £35,469 p.a.) depending upon qualifications and relevant experienceInformal enquiries to Dr. Peter Laslo tel +44 (0)113 343 8031 email p.laslo@leeds.ac.uk
Further details of the Institute’s research are available at http://www.limm.leeds.ac.uk
To download an application form and job details please visit our website. Alternatively application packs are also available from Mrs Cheryl Carr tel +44 (0)113 343 8649 email c.a.carr@leeds.ac.uk
Project title: Transcriptional control of multinucleated giant cells and osteoclasts Macrophages are able to fuse and differentiate into either multinucleated giant cells or osteoclasts. We have identified a novel transcriptional regulator that represses both multinuclear cell fates during macrophage development. This project will use ChIP-Seq in conjunction with bio-informatics to identify the target genes of the repressor during macrophage development and generate conditional knockout mice to genetically establish the role of this repressor in myelopoiesis.
You will have a recent PhD (or soon to be awarded) with a strong emphasis in molecular biology, cell biology, immunology or genetics. You will have practical experience in the culture of haematopoietic cells, recombinant DNA procedures and gene expression analysis. Knowledge of gene regulation in the haematopoietic system and a good understanding of modern concepts of gene regulation are required.
The Section of Experimental Haematology is a vigorous and highly interactive department, consisting of faculty members studying the molecular regulation of cell fate specification and differentiation during blood cell development. This is complimented by studies on the dysregulation of haematopoiesis in cancers (leukemias and lymphomas). You will join the Leeds Institute of Molecular Medicine (LIMM), a world-class multi-disciplinary research institute, dedicated to defining the molecules involved in human diseases.
University Grade 7 (£29,704 – £35,469 p.a.) depending upon qualifications and relevant experienceInformal enquiries to Dr. Peter Laslo tel +44 (0)113 343 8031 email p.laslo@leeds.ac.uk
Further details of the Institute’s research are available at http://www.limm.leeds.ac.uk
To download an application form and job details please visit our website. Alternatively application packs are also available from Mrs Cheryl Carr tel +44 (0)113 343 8649 email c.a.carr@leeds.ac.uk
Closing date 12 June 2009
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