Project description: Global screen of new putative antivirals in a high trough put setting at LCBU. Our approach has been enabled by a new complete replicating GFP expressing human adenovirus vector. This design allows assessment, in a whole cell context, of the antiviral effect of low molecular weight substances both of commercial origin and from a unique natural source. Structure activity analysis will be performed with the perspective to improve the efficacy and the toxicity profile of the identified lead compounds. The mechanism of action of promising antiviral candidates will also be analyzed.
More Information: Sweden: Postdoctoral position in Molecular Infection Biology/Microbiology and Chemical Biology
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