Highlights:
- PhD position is available to understanding kinase flexibility using new computational tools.
- The objective is to produce new computational tools for modelling large-scale conformational change in biomolecules.
- Project is funded for 4-year by BBSRC
- Stipend is tax-free (anticipated to be £15, 990)
- Full coverage of tuition fees and an industrial placement. Due to commence October 2010, the project is open to UK/EU* nationals only due to the nature of the funding.
- The study will develop new simulation-based tools, based on recent software developments in the computational biophysics group of Dr Bryce.
- This computational methodology will be applied to model the conformational rearrangements for selected, therapeutically important kinases.
- In collaboration with Johnson & Johnson, the project seeks to answer fundamental questions regarding the molecular features that underpin the conformational transitions of these flexible proteins.
- The study will be conducted within the Computational Biophysics and Drug Design group (
- Upon completion, the candidate would be ideally placed to progress into further computational medicinal chemistry research within the pharmaceutical industry or associated software companies.
- Applicants should hold, or expect to obtain, a minimum upper-second honours degree (or equivalent) in chemistry and should have an interest in learning molecular simulation techniques. A Masters qualification in chemistry and programming skills would be an advantage but are not essential.
- Any enquiries relating to the project and/or suitability should be directed to Dr Richard Bryce (richard.bryce@manchester.ac.uk).
- Applications should be directed to Dr Bryce and include a CV as well as contact details for two academic or professional referees.
- Closing date Monday 24 May 2010.
- Applicants must be UK/EU nationals as well as permanent residents of the
- More details http://www.pharmacy.manchester.ac.uk/
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